![]() ![]() Specifically, these refer to a part of the ‘spike’ glycoprotein (S-domain) which is needed to interact with endogenous receptors to facilitate membrane fusion and delivery to the cytoplasm. Image Credit: Volodymyr Dvornyk/ What is a receptor-binding domain (RBD)?Ī receptor-binding domain (RBD) is a short immunogenic fragment from a virus that binds to a specific endogenous receptor sequence to gain entry into host cells. Model of structure of novel coronavirus spike receptor-binding domain (pink) complexed with its receptor ACE2 (blue). These are also the primary targets in the prevention and treatment of viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the virus that causes COVID-19. Osman Shabir, PhD Reviewed by Sophia CoveneyĪ receptor-binding domain (RBD) is a key part of a virus located on its ‘ spike’ domain that allows it to dock to body receptors to gain entry into cells and lead to infection. ![]()
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